Video from Kevin Mangum, D.O. on YouTube
Explain spare receptors (receptor reserve) and their effect on agonist potency and on the action of irreversible antagonists.
Why this video
Explains how receptor-effector coupling creates spare receptors, altering agonist potency and modulating the concentration-response shift seen with irreversible antagonists.
Heads up
Refers to the agonist dissociation constant as Kd rather than KA, which this course uses for functional dissociation constants.
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