Video from Elliot Nicholson on YouTube

Describe the mechanisms of desensitisation: receptor uncoupling (phosphorylation by GRKs, PKA, PKC; β-arrestin binding), sequestration/internalisation, down-regulation and degradation, mediator depletion, increased drug metabolism and physiological adaptation.

Why this video

It walks through the molecular steps of receptor desensitisation using the prototypical beta-2 adrenoceptor, detailing receptor uncoupling, kinase phosphorylation, and internalisation.

Part of this line

Covers part of this objective. It leaves out: It focuses on receptor-level regulation and does not cover non-receptor mechanisms such as mediator depletion, increased drug metabolism, or physiological adaptation.

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