Video from Ninja Nerd on YouTube

Explain the G-protein cycle and the main effector pathways: Gs/Gi–adenylyl cyclase–cAMP–protein kinase A; Gq–phospholipase C–IP₃/DAG–Ca²⁺–protein kinase C; direct regulation of ion channels.

The part on this line: 2:32–3:10

Why this video

It walks through the primary Gs, Gi, and Gq second-messenger cascades step-by-step, explaining how adenylyl cyclase, cAMP, PKA, phospholipase C, IP₃, DAG, and calcium interact.

Part of this line

Covers part of this objective. It leaves out: It does not teach the direct regulation of ion channels by G-protein beta-gamma subunits, such as GIRK channels or presynaptic calcium channels.

Heads up

The video includes discussions of steroid hormone nuclear receptor signalling and clinical endocrine physiology that go beyond this pharmacology objective.

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