Molecular and Cellular Basis of Health and Disease I

1. 1 14:23 MLO1 Use anatomical and medical terminology, describe the methods used to gather information about the body, and relate structure to function and to clinical practice. Dr Matt & Dr Mike · 3 videos
2. 2 11:56 MLO2 Describe the structure of prokaryotic and eukaryotic cells and viruses, the organelles and their functions, and the cell membrane and its transport mechanisms. The Organic Chemistry Tutor · 3 videos
3. 3 17:04 MLO3 Describe the structure, reactions and functions of carbohydrates, lipids, proteins, enzymes and vitamins, and apply biochemical thermodynamics and enzyme kinetics. The Organic Chemistry Tutor · 3 videos
4. 4 11:09 MLO4 Explain the energy-generating pathways, their regulation and integration, and the clinical consequences of their disorders. Ninja Nerd · 3 videos
5. 5 12:40 MLO5 Describe cell division, cell growth and the basic concepts of medical genetics, and explain their consequences for health and disease. Professor Dave Explains · 3 videos
6. 6 37:13 MLO6 Describe the light and electron microscopic organisation of the basic tissues, including nervous tissue and nerve regeneration, and relate structure to function. HistoTube dr.Shereen Hamed · 2 videos
7. 7 21:59 MLO7 Explain homeostasis, the composition of body fluids, membrane potentials, the generation, propagation and recording of action potentials, synaptic transmission and cell signalling. Ninja Nerd · 3 videos
8. 8 8:20 MLO8 Describe the functional and applied anatomy of the upper limb and predict the effects of nerve injuries. Dirty Medicine · 3 videos

Biochemistry

1.1 Cell structure and organelles (Biochemistry)

9. 9 2:10 1.1.1 Distinguish prokaryotic and eukaryotic cells and viruses by structure, genome organisation and replication. Amoeba Sisters · 3 videos
10. 10 19:10 1.1.2 Describe the ultrastructure of the eukaryotic cell and the functions of its organelles: nucleus, ribosomes, rough and smooth endoplasmic reticulum, Golgi apparatus, lysosomes, peroxisomes, mitochondria and cytoskeleton. Siebert Science · 3 videos
11. 11 37:17 1.1.3 State the chemical constituents of the cell (water, ions, carbohydrates, lipids, proteins, nucleic acids) and their relative proportions. Organized Biology · 3 videos
12. 12 33:08 1.1.4 Relate organelle dysfunction to disease, for example lysosomal storage disorders and mitochondrial disorders. Ninja Nerd · 2 videos

1.2 Biochemical thermodynamics and high-energy compounds (Biochemistry)

13. 13 8:31 1.2.1 Explain enthalpy, entropy and the first and second laws of thermodynamics as they apply to living systems. Khan Academy · 3 videos
14. 14 24:18 1.2.2 Define Gibbs free energy, calculate ΔG and ΔG°′ and predict whether a reaction is spontaneous, including the effect of coupling reactions. Chad's Prep · 2 videos
15. 15 6:19 1.2.3 Explain why ATP serves as the energy currency of the cell and describe other high-energy compounds (phosphoenolpyruvate, creatine phosphate, 1,3-bisphosphoglycerate, thioesters). Mr Pollock · 2 videos

1.3 Carbohydrate structure and function (Biochemistry)

16. 16 22:01 1.3.1 Classify monosaccharides (aldoses and ketoses; trioses to hexoses) and describe their stereoisomerism, ring structures and anomers. The Organic Chemistry Tutor · 2 videos
17. 17 8:01 1.3.2 Describe the reactions of monosaccharides (oxidation and reducing properties, reduction to sugar alcohols, glycoside formation) and their clinical importance. The Tutor - Biochemistry · 3 videos
18. 18 10:20 1.3.3 Describe the structure and clinical importance of disaccharides (sucrose, lactose, maltose) and polysaccharides (starch, glycogen, cellulose, glycosaminoglycans). Andrey K · 3 videos

1.4 Lipid structure and function (Biochemistry)

19. 19 8:10 1.4.1 Classify fatty acids (saturated, unsaturated, essential, cis and trans) and describe the structure of glycerol and triacylglycerols. Diana Bedoya · 3 videos
20. 20 18:57 1.4.2 Describe the structure, classification and functions of phospholipids and sphingolipids, and the reactions of lipids (hydrolysis, saponification, peroxidation). Science Simplified · 3 videos
21. 21 6:15 1.4.3 Describe the clinical importance of lipids, including sphingolipidoses, trans fats and lipid peroxidation. Professor Dave Explains
22. 22 9:28 1.4.4 Explain the principles of separating lipids, including thin-layer chromatography. Professor Dave Explains · 3 videos

1.5 Amino acids and protein structure and function (Biochemistry)

23. 23 6:55 1.5.1 Classify amino acids by side-chain properties and explain their acid–base behaviour (pKa, isoelectric point). JJ Medicine · 3 videos
24. 24 8:49 1.5.2 Describe the primary, secondary, tertiary and quaternary structure of proteins and the bonds that stabilise each level. khanacademymedicine · 3 videos
25. 25 7:46 1.5.3 Classify proteins by shape and function and describe their reactions, including denaturation. Amoeba Sisters · 3 videos
26. 26 15:12 1.5.4 Explain the consequences of altered protein structure for health, for example sickle cell haemoglobin, collagen disorders and protein misfolding diseases. Ruby Joshi_ Excelsure Academy · 3 videos

1.6 Enzyme catalysis: properties, classification and kinetics (Biochemistry)

27. 27 7:04 1.6.1 Describe the general properties of enzymes and their classification into the six classes. khanacademymedicine · 3 videos
28. 28 16:33 1.6.2 Explain how enzymes lower activation energy, and the roles of the active site and of cofactors. The Organic Chemistry Tutor · 3 videos
29. 29 22:15 1.6.3 Explain Michaelis–Menten kinetics, and determine Km and Vmax from a Lineweaver–Burk plot. Ninja Nerd · 3 videos
30. 30 7:44 1.6.4 Describe the factors that affect enzyme activity (substrate concentration, temperature, pH). Cognito · 3 videos

1.7 Enzyme activity, regulation and inhibition (Biochemistry)

31. 31 32:35 1.7.1 Distinguish competitive, non-competitive and uncompetitive inhibition and identify each from kinetic plots. Ninja Nerd · 3 videos
32. 32 32:35 1.7.2 Explain irreversible inhibition with clinical examples (for example organophosphates and aspirin). Ninja Nerd
33. 33 28:40 1.7.3 Describe the regulation of enzyme activity: allosteric regulation, covalent modification, zymogen activation and control of enzyme synthesis. Last Minute Lecture · 3 videos
34. 34 13:05 1.7.4 Describe the clinical use of enzymes as diagnostic markers and drug targets. Dr.G Bhanu Prakash Animated Medical Videos · 3 videos

1.8 Vitamins, coenzymes and cofactors (Biochemistry)

35. 35 35:03 1.8.1 Define vitamins, coenzymes and cofactors and classify vitamins as water-soluble or fat-soluble, with their main sources. N'JOY Biochemistry
36. 36 29:19 1.8.2 Describe the coenzyme forms and functions of the B vitamins (thiamine, riboflavin, niacin, pantothenic acid, pyridoxine, biotin, folate, cobalamin) and vitamin C in metabolism and biological oxidation. Dr Matt & Dr Mike
37. 37 13:37 1.8.3 Describe the functions of vitamins A, D, E and K. Dr Matt & Dr Mike
38. 38 8:23 1.8.4 Describe the consequences of deficiency (for example beriberi, pellagra, scurvy, rickets, megaloblastic anaemia) and of toxicity (vitamins A and D). JJ Medicine

1.9 Membrane structure and transport (Biochemistry)

39. 39 39:16 1.9.1 Describe the composition of the cell membrane (phospholipids, cholesterol, proteins, carbohydrates) and the fluid mosaic model. Ninja Nerd · 3 videos
40. 40 13:42 1.9.2 Relate membrane composition to membrane fluidity and function. Andrey K · 3 videos
41. 41 10:50 1.9.3 Explain transport across membranes: simple diffusion, osmosis, facilitated diffusion, primary active transport (Na⁺/K⁺-ATPase), secondary active transport, endocytosis and exocytosis. Whats Up Dude · 3 videos
42. 42 5:04 1.9.4 Relate defects of membrane transport to disease, for example cystic fibrosis (CFTR) and cystinuria. Alila Medical Media · 2 videos

2.1 Carbohydrate metabolism I: digestion, glycolysis and its regulation (Biochemistry)

43. 43 38:06 2.1.1 Outline the digestion and absorption of carbohydrates. Ninja Nerd · 3 videos
44. 44 34:33 2.1.2 Describe the reactions of glycolysis, its energy yield under aerobic and anaerobic conditions, and the fate of pyruvate (pyruvate dehydrogenase, lactate). Ninja Nerd · 3 videos