Video from Ruby Joshi_ Excelsure Academy on YouTube

1.5.4 Explain the consequences of altered protein structure for health, for example sickle cell haemoglobin, collagen disorders and protein misfolding diseases.

Why this video

This video details the biochemical mechanism by which the Glu6Val mutation in the beta-globin chain alters the protein surface in the deoxygenated state, driving HbS polymerisation and cell sickling.

Part of this line

Covers part of this objective. It leaves out: It does not cover collagen disorders or protein misfolding diseases such as amyloidosis, prion diseases, or Alzheimer disease.

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