Necrosis and Apoptosis
Everything on necrosis and apoptosis including pathways in Apoptosis
Quick Rules
-
Time limit: 7 minutes
-
Multiple attempts are not allowed
-
All questions must be answered to submit
Share Quiz
Quiz Questions Preview
Question 1
What is the key characteristic that distinguishes apoptosis from necrosis?
Explanation
Apoptosis is a form of programmed cell death that is regulated and controlled, while necrosis is an uncontrolled process that typically leads to inflammation.
Question 2
Which of the following is NOT typically associated with necrosis?
Explanation
DNA fragmentation is more characteristic of apoptosis, whereas necrosis usually involves cell swelling and rupture.
Question 3
In which type of cell death do caspases play a crucial role?
Explanation
Caspases are a family of protease enzymes that are crucial to the process of apoptosis, leading to cellular degradation.
Question 4
Which signaling pathway is primarily involved in intrinsic apoptosis?
Explanation
The intrinsic pathway of apoptosis is regulated by Bcl-2 family proteins, which either promote or inhibit cell death.
Question 5
What role does the p53 protein play in apoptosis?
Explanation
The p53 protein is a key regulator that activates pro-apoptotic genes in response to cellular stress or DNA damage.
Question 6
Which of the following is a common morphological feature of apoptosis?
Explanation
Nuclear fragmentation is a hallmark of apoptosis, along with cellular shrinkage and chromatin condensation.
Question 7
Which of the following apoptotic stimuli primarily activates the extrinsic pathway?
Explanation
The extrinsic pathway of apoptosis is initiated by the binding of death ligands, such as Fas ligand, to their respective receptors.
Question 8
What is the main consequence of necrotic cell death?
Explanation
Necrotic cell death typically leads to inflammation due to the uncontrolled release of cellular contents into the surrounding tissue.
Question 9
Which component is crucial for the formation of apoptotic bodies during apoptosis?
Explanation
Phosphatidylserine externalization is a marker of apoptosis and is vital for the formation of apoptotic bodies.
Question 10
Which of the following proteins is anti-apoptotic?
Explanation
Bcl-2 is an anti-apoptotic member of the Bcl-2 family, helping to prevent apoptosis and promote cell survival.
Question 11
During which cellular process is mitochondrial outer membrane permeabilization (MOMP) most likely to occur?
Explanation
Mitochondrial outer membrane permeabilization is a critical event in the intrinsic pathway of apoptosis, leading to the release of cytochrome c.
Question 12
What type of cell death is characterized by the formation of large pores in the plasma membrane?
Explanation
Necrosis often involves the formation of large pores in the plasma membrane, leading to loss of cell integrity.
Question 13
What is the term used to describe the process of programmed cell death?
Explanation
Apoptosis refers to programmed cell death, a vital process for maintaining cellular health and homeostasis.
Question 14
Which of the following statements about necrosis is true?
Explanation
Necrosis typically occurs in response to injury or stress and is characterized by uncontrolled cell death, leading to inflammation.
Question 15
Which of the following factors can induce apoptosis?
Explanation
Targeted anticancer therapies are designed to induce apoptosis in cancer cells, promoting cell death while sparing normal cells.