GEMP - Pharmacokinetics
Pharmacokinetics Introduction Pharmacokinetics is the branch of pharmacology that studies what the body does to drugs, focusing on the absorption, distribution, metabolism, and excretion (ADME) of pharmaceuticals. Understanding pharmacokinetics is crucial for medical students and healthcare professionals, as it provides insights into drug action, efficacy, safety, and individual patient varia...
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Question 1
What does pharmacokinetics primarily study?
Explanation
Pharmacokinetics is concerned with what the body does to drugs, particularly absorption, distribution, metabolism, and excretion (ADME).
Question 2
Which factor does NOT influence drug absorption?
Explanation
While route of administration, gastric pH, and drug formulation influence absorption, the patient's age is not a direct factor in the absorption process.
Question 3
What is the primary site of drug metabolism in the body?
Explanation
Metabolism primarily occurs in the liver, where drugs are biochemically modified.
Question 4
Which phase of drug metabolism involves conjugation reactions?
Explanation
Phase II reactions involve conjugation to produce more water-soluble metabolites, making drugs easier to excrete.
Question 5
What is 'Clearance' in pharmacokinetics?
Explanation
Clearance refers to the rate at which a drug is removed from the body, typically measured in volume of blood cleared per unit of time.
Question 6
Why is understanding half-life important in pharmacokinetics?
Explanation
Half-life affects how frequently a drug needs to be administered to maintain therapeutic levels.
Question 7
Which route of drug excretion eliminates drugs primarily via bile?
Explanation
Biliary excretion involves the elimination of drugs secreted into bile, which is then excreted in feces.
Question 8
What term describes the proportion of a drug that reaches systemic circulation in an active form?
Explanation
Bioavailability refers to the fraction of an administered dose of unchanged drug that reaches the systemic circulation.
Question 9
Which of the following statements about protein binding is true?
Explanation
Protein binding affects the free concentration of a drug, influencing its pharmacological effect and therapeutic efficiency.