cellular adaptation
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Question 1
Multiple choiceA 35-year-old man presents with cardiac hypertrophy due to chronic hypertension. Which of the following best explains the cellular adaptation observed in this scenario?
Explanation
Cardiac hypertrophy is primarily an increase in cell size in response to increased workload, which is a classic example of hypertrophy.
Question 2
Multiple choiceA patient suffering from chronic gastroesophageal reflux disease develops Barrett's esophagus. What type of cellular adaptation has occurred?
Explanation
Barrett's esophagus is a result of metaplasia, where the normal squamous epithelial cells of the esophagus are replaced by columnar cells in response to chronic irritation.
Question 3
Multiple choiceAfter a severe illness, a 65-year-old woman has noticed a significant decrease in muscle mass. What cellular response best describes this condition?
Explanation
Atrophy refers to the decrease in cell size or number, which can be observed in muscle tissue following disuse or severe illness.
Question 4
Multiple choiceIn a laboratory, a scientist exposes cells to a persistent noxious stimulus. After some time, the cells start to display abnormal growth patterns. Which cellular alteration might this represent?
Explanation
Dysplasia is characterized by the presence of abnormal cells within a tissue, often resulting from chronic irritation or noxious stimuli.
Question 5
Multiple choiceA physician observes that a tissue sample has an increased number of cells due to a specific stimulus. These cells are identical in structure and function. What cellular adaptation does this indicate?
Explanation
Hyperplasia is an increase in the number of cells, leading to tissue enlargement, with the cells maintaining their normal structure and function.
Question 6
Multiple choiceIn a tissue culture study, a researcher finds that cells exposed to high levels of cortisol develop enlarged organelles. What cellular adaptation is likely occurring?
Explanation
Hypertrophy can occur due to hormonal stimulation, leading to enlarged cells and organelles as a response to the increased workload.
Question 7
Multiple choiceA researcher is studying the effects of chronic inflammation on tissue. What cellular change might occur if the epithelial cells undergo transformation to a different cell type?
Explanation
Metaplasia refers to the replacement of one differentiated cell type with another, often seen in response to chronic inflammation.
Question 8
Multiple choiceIn a clinical observation, a patient shows signs of tissue thickening in response to irritants over time. Which form of adaptation is likely responsible for this change?
Explanation
Hyperplasia can result in tissue thickening as an adaptive response to chronic irritants, leading to an increase in the number of cells.
Question 9
Multiple choiceA biopsy from a precancerous lesion contains cells that show abnormal sizes and shapes but are not invading other tissues. How would you classify this cellular change?
Explanation
Dysplasia denotes a disordered growth, where cells exhibit abnormal size and shape, often associated with precancerous conditions.
Question 10
Multiple choiceFollowing a smoking cessation program, a patient notes improvements in their respiratory epithelium. What type of cellular response is this indicative of?
Explanation
When a noxious stimulus like smoking is removed, metaplasia can revert to normal tissue over time, demonstrating the cells' adaptability.